INGEBI   02650
INSTITUTO DE INVESTIGACIONES EN INGENIERIA GENETICA Y BIOLOGIA MOLECULAR "DR. HECTOR N TORRES"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Selective loss of dopamine D2 autoreceptors reveals crucial role of presynaptic regulation of dopamine release.
Autor/es:
BELLO GAY, E; LOVINGER, D; RUBINSTEIN, M; MATEO GONZÁLEZ, Y
Lugar:
Brussels, Belgium
Reunión:
Conferencia; 13th International Conference on In Vivo Methods; 2010
Resumen:
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Dysregulation of dopamine transmission
contributes to several neurological disorders including addiction and
schizophrenia. Nowadays, the use of D2 receptor ligands to treat
these disorders is widely used. D2 dopamine receptors are expressed as postsynaptic
receptors and as presynaptic autoreceptors. For the last three decades many
efforts have been taken into elucidate the precise role of D2 dopamine
autoreceptors at regulating dopamine transmission. It is well established now
that dopamine release from dopamine neurons can be modulated by several
factors. Activation of dopamine autoreceptors located at the soma level
decreases the firing rate of dopaminergic neurons. Dopamine D2 autoreceptors
regulate dopamine release as well as dopamine synthesis. In addition, the
introduction of D2 null mutant mice allowed the study of the regulation of
dopaminergic transmission by these receptors although without presynaptic
selectivity. Some groups using these lines of mice have proposed that long-term
adaptations occur in dopamine release and uptake in response to the lack of
both postsynaptic and presynaptic D2 activity. The aim of this study is to
determine for the first time the level of significance of D2 autoreceptor
regulation on central dopaminergic system and to evaluate behavioral and
neurochemically the consequences of the loss of presynaptic D2 autoreceptors.