Antioxidant action of Cannabis sativa Resin and CBD and synergism induced by Larrea divaricata and Tilia x viridis extracts

SAINT MARTIN MALÉN; PERALTA IGNACIO; SILVA SOFRÁS FRESIA; COGOI LAURA; VAN BAREN CATALINA; ALONSO MARÍA ROSARIO; ANECINI CLAUDIA

Mar del Plata

Otro; Reunión anual SAIC SAFE SAB SAP 2019; 2019

SAIC SAFE SAB SAP

Cannabissativa L.(Cannabaceae) is a medicinal plant used as anticonvulsant in refractoryepilepsy in kids. Convulsions induce oxidative stress (OS) in cerebraltissues which affects the normal function of the central nervous systemaltering cognitive functioning. The synergisticeffects of plants could not only improve therapeutic effects butalso mitigate adverse effects. Larrea divaricata Cav.(Zygophylliaceae) is an autochthonous plant with a well documented antioxidantactivity and Tilia viridis ssp x moltkei (Malvaceae) is a plantused for its anxiolytic effects. The purposeof this work was to evaluate the antioxidant activity of an ethanolicextract (EEC) of C. sativa, studying the participation of the cannabinoidCBD in its action and to evaluate for the first time the possiblesynergistic combination of EEC with aqueous extracts of L. divaricata (AEL)and Tilia x viridis (AET).