Hybrid thermosensitive-nanogels based on N-vinylcaprolactam

SONZOGNI, A.S.; GONZÁLEZ, V.D.G.; VAILLARD, S.E.; PASSEGGI (JR), M.C.G.; GUGLIOTTA, L.M.; MINARI, R.M.

Porto de Galinhas, Brazil, 12-16 October

Simposio; XIV SLAP/XII CIP, XIV Latin American Symposium on Polymers and XII Ibero American Congress on Polymers; 2014

ABPol Associação Brasileira de Polímeros

This work presents a semibatch strategy to produce hybrid nanogels with core-shell morphology. The synthesized nanogels have a core of poly(N-vinylcaprolactam) (PVCL), a biocompatible polymer with a phase transition closed to the physiological temperature, and a shell of poly(butyl acrylate) (PAcBut) that provides the properties of adhesiveness and film formation. This nanogels could be directly used in transdermal drug release, without requiring a support and adhesive matrix. Morphology, particle diameter and thermal response of the nanogels were evaluated along the work.