INTEC 05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Towards a Physician-Oriented Software for HIV Therapy Design
Autor/es:
VICENTE COSTANZA; PABLO S. RIVADENEIRA; FEDERICO BIAFORE; CARLOS D'ATTELLIS
Lugar:
Rosario
Reunión:
Congreso; RPIC 2009 - XIII Reunión de Trabajo para el procesamiento de la Información y Control; 2009
Institución organizadora:
Universidad de Rosario - RPIC
Resumen:
Antiretroviral therapies allowing forregular medical intervention in an optimal feedbackrole are substantiated. Individual therapies areevaluated from a multi-objective cost perspective.The dynamics of the control system is governed bythree state variables: healthy and infected T-cells,infected T-cell and viral particles. The drug doseadministrated to the patient is taken as the controlvariable. One case is discussed: beginning of theinfection. Both open-loop and closed-loop results arepresented. Dynamic Programming has beenemployed in the numerical treatment of the problem.A software package is envisioned to assist physiciansin assessing the patient state, estimatingantiretroviral dose prescriptions for the wholetreatment period, simulating the patients evolution,eventually correcting the original sequence inpresence of incoming data, and evaluating combinedcosts of alternative treatment strategies.
