INVESTIGADORES
ZOLD Camila Lidia
congresos y reuniones científicas
Título:
Modulation of theta band power in dorsomedial striatum signals reward in a virtual reality exploration task
Autor/es:
MARÍA ALEJANDRA PROST; MARIO GUSTAVO MURER; CAMILA L. ZOLD
Reunión:
Congreso; XXXIV Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias; 2019
Resumen:
Oscillations of local field potential activity (LFP) reflect the coordinated activity of groups of neurons and have been associated with network-level computations. Striatal oscillations are modulated during learning and space navigation tasks, and it has been proposed that they can influence information processing between brain structures. However, little is known about the role of striatal LFP oscillations in reward signaling.Using a virtual reality task, we evaluated if theta band LFP modulation in dorsomedial striatum is involved in reward signaling. Head fixed mice explore a virtual linear track. A sequence of licks is required to obtain a reward upon reaching a rewarded area. We used an array of four chronically implanted tetrodes to record single unit and LFP activity in dorsomedial striatum.We found a strong modulation of theta oscillations during our task associated with reward consumption. Interestingly, this increased theta power is absent if the reward is omitted. Also, theta power signaling reward was higher than theta power during running periods. In addition, we found that a big percentage of neurons recorded in dorsomedial striatum are phase-locked to the theta rhythm. To analyze whether the theta rhythm was locally generated, we performed our analysis with a local reference and found that these theta modulations are still present, which suggests that they are locally generated and a reflection of circuit-level codification of reward in this structure.