INVESTIGADORES
ABATE Paula
congresos y reuniones científicas
Título:
Moderate ethanol exposure during late gestation reproduces behavioral patterns of Attention Deficit Hyperactivity Disorder in periadolescent Wistar rats.
Autor/es:
PISANO MV; ABATE P; PAGLINI MG
Lugar:
Buzios, Brasil
Reunión:
Congreso; I Congreso IBRO/LARC de Neurociencias de América Latina, Caribe y Península Ibérica; 2008
Institución organizadora:
IBRO/LARC de Neurociencias de América Latina, Caribe y Península Ibérica.
Resumen:
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Attention
Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental psychiatric
syndrome characterized by deficits in filtering irrelevant information,
inattention, poor behavioral inhibition (impulsivity) and hyperactivity that
affects 8-12% of children of worldwide (1). The main treatment since the 1930s,
has involved the use of psychostimulant compounds, such as methylphenidate and
amphetamine. These drugs enhance neurotransmission of dopamine and
norepinephrine. Paradoxically, psychostimulants exert therapeutical benefits,
attenuating hyperactivity and often improve cognitive performance (2).
ADHD is a
heterogeneous disorder, probably as a result of different combinations of
genetic and environmental factors (3). Several studies indicate that pregnancy
and delivery complications raise the risk for ADHD. Prospective studies of
infants show that fetal exposure to maternal alcohol use leads to behavioral,
cognitive, and learning problems that could present as ADHD (4).
The main goal of the present study is to
investigate if the exposure to a moderate ethanol dose, during late gestation,
is sufficient to produce abnormal behaviors, similar to those observed in ADHD.
Additionally, we also intend to establish if metylphenidate (MPH) ameliorates
these behavioral alterations.
