IDIM 12530
INSTITUTO DE INVESTIGACIONES MEDICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Cardiac Hypertrophy in obesity: Leptin-TRH interaction.
Autor/es:
AISICOVICH MAIA; TOBLLI, J; PERES DIAZ LUDMILA; LANDA, MARIA SILVINA; SCHUMAN, MARIANO LUIS; GARCÍA SILVIA INES
Lugar:
Mar del Plata
Reunión:
Congreso; LXIII Reunión Anual de la Sociedad Argentina de Investigación Clínica; 2018
Institución organizadora:
Sociedad Argentina de Investigacion Clinica
Resumen:
Cardiac TRH induce left ventricular hypertrophy (LVH) and fibrosis, its inhibition prevent hypertrophy.The adiponectin leptin induces TRH in CNS. We hypothesized that in obesity, the increase of TRH induced by hyperleptinemia is responsible of the LVH, until now mostly attributed to pressure load. We studied obese Agouti mice suffering hypertension with hyperleptinemia and found LVH with increased TRH gene expression. Consequently we found higher (p
