Hemoxygenase-1 involvement in breast cancer

ALONSO, E.N.; FERRONATO, M.J.; IBARRA, A.; FACCHINETTI, M.M; COLÓ, G.P.; MASCARÓ, M.; AREVALO, J.; CURINO, A.C.; GANDINI, N.A.; FERMENTO, M.E.; ABBA, M.C.; BARRERA LAMAS, N.

Bariloche

Simposio; The Fourth South American Symposium in Signal Transduction and Molecular Medicine; 2018

HO-1 is an enzyme involved in cellular responses to oxidative stress and has also been shown to regulate processes related to cancer progression. In this regard, HO-1 has been shown to display a dual effect with either antitumor or protumor activity, being this also true for breast cancer (BC). On the other hand, it has been reported that HO-1 can translocate to multiple subcellular compartments and can have non-enzymatic signaling roles. Thus, in the nucleus the protein may act as a transcriptional co-regulator protein and can bind and modulate other important proteins. In this work we intended to address this discrepancy regarding the role of HO-1 in BC. In vivo experiments showed that both pharmacological activation and genetic overexpression of HO-1 reduced the tumor burden in two different animal models of BC. Furthermore, the activation of HO-1 in several BC cell lines reduced cellular viability by inducing apoptosis (p