Study of Risk Factors for Low Bone Mass in Postmenopausal Women from Argentina

BRANCE ML; LARROUDÉ MS; KOHAN MP; FINUCCI CURI P; CURTI AC; BRUN LR

Quito

Congreso; 2019 PANLAR Meeting; 2019

PANLAR

Osteoporosis is a skeletal disorder characterized bycompromised bone strength, which predisposes to increased risk of fracture. Thesefractures can cause hospitalizations, and a direct healthcare cost each year.Fracture also results in loss of function and has a negative impact onpsychological status. Moreover, the risks factor could affect treatmentefficacy. Objective: The aim of thisstudy was study the more frequent risk factors for low bone mass in postmenopausalwomen. Methods: Aretrospective and observational study were carried out. The clinical records ofpostmenopausal women derived to our center for bone mass study were analyzed. Atotal of 347 women were included in this study Exclusion criteria: autoimmunedisease, malabsorption disease, hepatic or renal chronic failure, diabetes,other bone disease, patients with AIDS, tuberculosis, hypertiroidism or treatedwith anticonvulsivant. The results are expressed as mean±SD. Results:.The main characteristic were= age: 66.5±10.0 [36-91]; menopause: 48.1±5.6, BMI:26.7±4.9 (<18.5=1.5%; 18.5-24.9=39.1%; 25-29.9=39.4%; >30=20%); calciumintake >500 mg/day: 26.5%; current smoking: 17.4%; alcohol 3 or moreunits/day: 12.3%; parent fractured hip: 8.7%. The 29% was treated to bone mass,90.7% with biphosphonates and 36.1% had been switched to a second drug.The 43.2%received vitamin D supplement. The basal lumbar spine bone mineral density(BMD) [Hologic] was 0.908±0.151 g/cm2, T-score -1.8±1.3 and thebasal femoral neck BMD was 0.732±0.129, T-score -1.6±1.1. According todensitometry evaluation, 35.9% had osteoporosis, 45.2% osteopenia and 18.9%normal. However, 20.7% showed vertebral fracture (VF) and 20.2% non VF. Only 2.6%of VF were symptomatic. The biochemical parameters were= calcium: 9.4±0.6mg/dl; phosphate: 3.5±0.6 mg/dl; parathormone: 67.8±96.7 pg/ml [range 17-1424];Dpd: 8.08±3.06 nm/mM/Cr; 25(OH)vitamin D: 26.3±11.9 ng/ml. Finally, 21.6% hadsecondary hyperparathyroidism, 2% primary hyperparathyroidism (1 case ofcarcinoma) and 11.53% hipercalciuria. Conclusions:High percentage of hyperparathyroidism, vitamin D deficiency, low calciumintake and vertebral and non vertebral fractures were found. On the other hand,the classical risk factors as the percentage of patients with parent fracturehip, alcoholism, current smoking, were less frequent than our findings.