mQACC: A community-led initiative to promote quality assurance and quality control in untargeted metabolomics research

ABBAS BANDUKWALA; KRISTA ZANETTI; RICHARD BEGER; AIKO BARSCH; CLARY CLISH; BIANCA BETHAN; SURAJ DHUNGANA; SURENDARA DASARI; ANNIE EVANS; WARWICK DUNN; THOMAS FLYNN; STEVE FISCHER; MAJDA HAZNADAR; CHARLES GRIESER; PING-CHING HSU; DAVID HERRINGTON; MAUREEN KACHMAN; CHRISTINA JONES; FADI ABDI; MATTHEW LEWIS; JENNIFER KIRWAN; DAN BEARDEN; SVEN MEYER; KATRICE LIPPA; DAVID BROADHURST; IOANNA NTAI; MARIA EUGENIA MONGE; CLAIRE O'DONOVAN; RUI PINTO; LESLIE DERR; MARY PLAYDON; SHARON ROSS; TIM EBBELS; ROBERTO FLORES; MICHAEL SCHMIDT; AMANDA SOUZA; JINCHUN SUN; GEORGIOS THEODORIDIS; THOMAS HARTUNG; FREDERICO TORTA; VIDYA VELAGAPUDI ; RICK HIGASHI; MUKESH VERMA, ; DAJANA VUCKOVIC; JUDITH JANS; LI-RONG YU; ANDRE KLEENSANG; IAN WILSON; PADMA MARUVADA; JONATHAN MOSLEY,; GEORGE PAPANICOLAOU; DAN RAFTERY; TRACEY SCHOCK; FARIBA TAYYARI; BALJIT UBHI; MARK VIANT; TILMANN WALK

Conferencia; Metaboloimcs 2019; 2019

The Metabolomics Society

The metabolomics Quality Assurance and quality Control Consortium (mQACC) is a community-led initiative to promote quality assurance (QA) and quality control (QC) in untargeted metabolomics research. mQACC was established through a National Institutes of Health-funded meeting in October 2017. Data from a survey published by Dunn, et al. (Metabolomics, 2017) was used to establish meeting objectives: 1.) identify the most useful metrics for assessing study and data quality for untargeted metabolomic studies; 2.) identify and prioritize processes to ensure appropriate reporting of QA/QC data; and 3.) identify and prioritize the types of test materials that are needed in the field of metabolomics for QA/QC in untargeted studies. Key priorities were identified and scored for importance, resulting in several primary themes. Although priorities were identified for long-term efforts, three immediate priorities were moved forward: 1.) publish a workshop report (Beger et al., Metabolomics, 2019); 2.) document and subsequently publish the complete experimental procedure for untargeted metabolomics; and 3.) identify 2-3 reference materials to be developed quickly. mQACC currently includes over 55 representatives from the North America, South America, Europe, and Asia, including instrument manufacturers, commercial laboratories, and government and academic stakeholders. The consortium is currently addressing their initial priorities, as well as expanding these efforts. mQACC has also established several working groups to achieve their objectives, including ones focusing on experimental procedures, reference materials, QC best practices, and reporting standards. In addition to describing the mQACC priorities, we will highlight how the metabolomics community can get involved in this important initiative.