INSIBIO 05451
INSTITUTO SUPERIOR DE INVESTIGACIONES BIOLOGICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Effect of the charge on the interaction of L-cysteine and its esters with monolayers of DPPC
Autor/es:
ARIAS, JUAN MARCELO; BEN ALTABEF, AÍDA; DUPUY, FERNANDO G.; DIAZ, SONIA
Lugar:
La Plata
Reunión:
Congreso; XLVII Reunión Anual de la Sociedad Argentina de Biofísica; 2018
Institución organizadora:
Sociedad Argentina de Biofísica
Resumen:
The surface behaviorof the aminoacid cysteine was studied by means of Langmuir monolayer technique.The effect of charge on monolayers made of cysteine and three esters derivativeswith dipalmitoylphosphatidylcholine (DPPC) was investigated bypreparing un-buffered and borate buffered (pH ??) subphases. Molecularinteractions between the cysteine derivatives L-cysteine, L-cysteine ethylester, L-cysteine methyl ester and N-acetylcysteine with DPPC monolayers werestudied measuring the change in the surface tension upon aminoacid injection in the subphase whilstkeeping lipid molecular density and lateral packing controlled. The resultsindicate that, although the different derivatives of cysteine presented lowsurface activity, they were able to favourably interact with DPPC monolayers.Also, compression isotherms experiments in binary mixtures indicate that themore surface active compounds stabilized the gel phase of DPPC. The charge oncysteine and its derivatives increased the observed effects.
