BECAS
LOMBARDI Antonella
congresos y reuniones científicas
Título:
Differentiation of pluripotent stem cells into mesenchymal stem cells in a suspension culture using commercial microcarriers
Autor/es:
LOMBARDI ANTONELLA; BLOND OLIVIER; BIANI MARÍA CELESTE; ABAN CYNTIA; MORO LUCÍA; LA GRECA ALEJANDRO; LUZZANI CARLOS DANIEL; MIRIUKA GABRIEL SANTIAGO
Lugar:
CABA
Reunión:
Congreso; SAIC; 2018
Institución organizadora:
Sociedad Argentina de Investigación Clínica
Resumen:
Mesenchymal stem cells (MSC) multipotentiality and immunomodulatory capacity are characteristics particularly appealing for the field of regenerative medicine. Despite the numerous clinical trials involving these cells, their large-scale production has drawbacks given the large amounts required for therapy and the loss of their therapeutic properties because they rapidly reach senescence. This highlights the need to have standardized and economically viable MSC procurement processes. Our laboratory has recently established a new way to generate MSC from Pluripotent Stem Cells (PSC). The aim of this project is to adapt this protocol to a suspension culture on microcarriers in order to develop a valid platform for obtaining MSC compatible for clinical use and without quantity limits.
