Cells expressing HTLV-1 genes, Tax and HBZ, showed different patterns of cytolysis by human γδ T cells and NK cells

RUGGIERI M; BERII C; QUIROGA F; POLO V; FISH P; BIGLIONE M

Conferencia; The 19th International Conference on Human Retrovirology: HTLV and Related Viruses,; 2019

Expression of HTLV-1 genes Tax and HBZ by target cells produce different effects over cytolysis by NK and γδ Tcells. The cytotoxicity by Vγ9/Vδ2 T cells against cells expressing viral proteins suggest that γδ T cells play arole in the immunosurveillance against HTLV-1. This finding are supported by cDNA spectratyping and by flowcytometry that showed Vδ2 T cells are decreased in HTLV-1 patients. Besides the cytotoxic effect by γδ T cells islikely not related to an upregulation of surface butyrophilins; further experiments need to be performed in orderto understand the cause of the different cytolysis patterns.