Uric acid levels in gestations complicated with preeclampsia and fetal growth restriction.

ANA IRENE COROMINAS; SILVIA BALCONI; MARÍA ORTIZ; BERNARDO MASKIN; MARTÍNEZ, NORA; ALICIA DAMIANO

Congreso; REUNION CONJUNTA DE SOCIEDADES DE BIOCIENCIAS; 2018

Preeclampsia is a pregnancy disorder characterized by the onset ofhypertension after 20 weeks of gestation. Although its etiology is unknown,inadequate placentation and maternal vascular dysfunctionwere associated with multiple complications and increased maternaland fetal morbimortality.Preeclampsia is subdivided into early (before 34+0 weeks) and late(after 34+0 weeks) onset, with or without intrauterine fetal growthrestriction (IUGR).The identification of pregnant women at risk for preeclampsia is stilldifficult and current biomarkers fail to differentiate preeclampsia associatedto IUGR with pure IUGR without preeclampsia.In other tissues, it was reported that an increase in serum uric acidmay be related to endothelial dysfunction. Previously, we demonstratedthat uricemia increased in preeclamptic pregnancies, andthe uricemia ratio after and before the 20th week of gestation maybe useful to discard those women who are not at risk of developingpreeclampsia.Our aim was to evaluate the behavior of the uricemia ratio in pregnanciescomplicated by IUGR associated or not to preeclampsia.A retrospective descriptive-quantitative study was carried out inall women who attended their pregnancy at the Hospital Posadasduring 2014. Uricemia ratio (uricemia after 20th week /uricemia before20th week) was calculated in women who presented IUGR insimple pregnancies associated or not to preeclampsia.In 3794 simple gestations analyzed, 214 presented IUGR. In gestationscomplicated with preeclampsia associated to IUGR 58%of the newborns were under percentile 3, whereas in pregnancieswith pure IUGR without preeclampsia, only 33% of the newbornswere under percentile 3. Uricemia ratios were higher in women withpreeclampsia and IUGR than in those who only presented IUGR(2.03±0.67 vs 1.23±0.30, p