Clinical and immunological disease patterns of primary Sjögren syndrome driven by gender and age at diagnosis

ZEHER MARGIT; RAPHAELE SEROR; XAVIER MARIETTE; ROBERTA PRIORI; BERKAN ARMAGAN; MARIE WAHREN-HERLENIUS; ELENA BARTOLONI; YASUNORI SUZUKI; PIOTR WILAND; HENDRIKA BOOTSMA; VALERIE DEVAUCHELLE-PENSEC; VIRGINIA FERNANDES MOÇA TREVISANI; STEVEN E. CARSONS; MOREL, JACQUES; RAMOS CASALS MANUEL; KOSTOV, BELCHIN; THOMAS MANDL; CHIARA BALDINI; DEBASHISH DANDA; GABRIELA HERNANDEZ-MOLINA; SEUNG-KI KWOK; DAMIEN SENE; ROSER SOLANS; VALERIA VALIM; GUADALUPE FRAILE; ROBERTO GIACOMELLI; RETAMOZO SOLEDAD; MICHELE BOMBARDIERI; KATHY SIVILS; SANDRA G. PASOTO; XIAOMEI LI; FABIOLA ATZENI; JACQUES-ERIC GOTTENBERG; PILAR BRITO-ZERÓN; LUCA QUARTUCCIO; AIKE A. KRUIZE; SONJA PRAPROTNIK; MAUREEN RISCHMUELLER; DAVID ISENBERG; GUNNEL NORDMARK; TAKASHI NAKAMURA; BENEDIKT HOFAUER; DANIEL HAMMENFORS; TAMER A GHEITA; VOLLENVEIDER, CRISTINA

Washington DC

Simposio; 14th International Symposium on Sjögren's Syndrome; 2018

Johns Hopkins University School of Medicine

Objective. To analyse how the epidemiological profile modifies systemic involvement measured at the time of diagnosis in a large international cohort of patients diagnosed with primary Sjögren syndrome (SS).Patients. The Big Data Sjögren Project is an international, multicentre registry formed in 2014 to take a ?high-definition? picture of the main features of primary SS at diagnosis by merging international SS databases. By October 2017, the database included 9545 consecutive patients recruited from 22countries of the five continents.Results. Baseline ESSDAI score was available in 9118 patients (93% female, mean age at diagnosis 53 years). The median ESSDAI score at diagnosis of the entire cohort was 4 (IQR 1-8). Men showed a higher systemic activity at diagnosis than women, including a higher median ESSDAI score (5 vs 4, p