Clinical And Immunological Primary Sjögren Syndrome? Disease Patterns Are Driven By Gender And Age At Diagnosis.

HERNANDEZ-MOLINA GABRIELA; PASOTO SG; SIVILS KATHY; LI X; GOTTENBERG JE; QUARTUCCIO LUCA; KWOK SK; SENE D; SOLANS ROSER; PIOTR WILAND; HENDRIKA BOOTSMA; DEVAUCHELLE-PENSEC V; HAMMENFORS DANIEL; ATZENI FABIOLA; RAMOS CASALS MANUEL; RETAMOZO SOLEDAD; FERNANDES MOÇA TREVISANI V; ZEHER MARGIT; SEROR R; MARIETTE XAVIER; PRIORI ROBERTA; KRUIZE AA; PRAPROTNIK SONJA; RISCHMUELLER M; DAVID ISENBERG; GUADALUPE FRAILE; GIACOMELLI ROBERTO; VALIM VALERIA; BOMBARDIERI MICHELLE; KOSTOV B; GHEITA TA; MANDL THOMAS; VOLLENVEIDER C; BALDINI CHIARA; DANDA D; ARMAGAN BERKAN; WAHREN-HERLENIUS MARIE; ELENA BARTOLONI; YASUNORI SUZUKI; GUNNEL NORDMARK; TAKASHI NAKAMURA; HOFAUER B; CARSONS SE; MOREL J; BRITO ZERON PILAR

Buenos Aires

Congreso; XX CONGRESO DE LA LIGA PANAMERICANA DE ASOCIACIONES DE REUMATOLOGÍA (PANLAR); 2018

PANLAR

Objective: To examine how the epidemiological profile modifies systemic involvement measured at the time of diagnosis in a large international cohort of patients diagnosed with primary Sjögren syndrome (SS).Patients: The Big Data Sjögren Project is an international, multicentre registry formed in 2014 to take a ?high-definition? picture of the main features of primary SS at diagnosis by merging international SS databases. By October 2017, the database included 9545 consecutive patients recruited from 22 countriesof the five continents.Results: Baseline ESSDAI score was available in 9118 patients (93% female, mean age at diagnosis 53 years). The median ESSDAI score at diagnosis of the entire cohort was 4 (IQR 1-8). Men showed a higher systemic activity at diagnosis than women, including a higher median ESSDAI score (5 vs 4, p