BECAS
SUBERBORDES Melisa Del Valle
congresos y reuniones científicas
Título:
Angiotensin II: Key rol in mammary gland involution and mammary tumours
Autor/es:
SUBERBORDES, MELISA DEL VALLE; CAMBADOS, NADIA; ÁNGELA LARA; EVA WERTHEIMER
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión Conjunta de la Sociedad Argentina de Investigación Clínica (SAIC), la Sociedad Argentina de Inmunología (SAI) y la Sociedad Argentina de Fisiología (SAFIS); 2018
Institución organizadora:
Sociedad Argentina de Investigación Clínica (SAIC), la Sociedad Argentina de Inmunología (SAI) y la Sociedad Argentina de Fisiología (SAFIS)
Resumen:
Angiotensin (Ang) II, the main effector peptide of the renin-angiotensin system, has been implicated in multiple aspects of cancer progression such as proliferation, migration, invasion, angiogenesis and metastasis. Our previous studies have shown that AngII through AT1 receptor induces STAT3 activation, epithelial apoptosis and MMP-9 activation during mammary gland involution. The lack of AT1 receptor caused a delay in mammary involution. In this study, we show that AngII through AT1 receptor has a key role as tumour promoter on breast cancer cell lines. We found that AngII induced cell invasion (2 fold change p
