Effect of systemic administration of mGlu3R agonist in a model of cerebral ischemia

J. TURATI; A. NUNES SANTIAGO; D. RAMIREZ; L. CARNIGLIA; J. SABA; C. CARUSO; D. DURAND; R. WEFFORT DE OLIVEIRA; M. LASAGA

CORDOBA

Congreso; XXXIII Congreso Anual de la SAN; 2018

SAN

Chronic cerebral hypoperfusion (CCH) resembles central changes in aging-related vascular dementias and Alzheimer´s disease (AD). Our group has demonstrated, in vitro, that astroglial subtype 3 metabotropic glutamate receptors (mGlu3R) present protective actions against neurotoxic agents including A. However, contradictory results were reported when mGlu3R ligands were administered in vivoWe examined the effect of the mGlu3R agonist, LY376298 (LY) 1mg/kg i.p., in middle aged rats with CCH. Memory retention was evaluated using the aversive radial maze and NeuN and GFAP expression were determined by immunohistochemistry.All groups showed increased latency and number of reference memory after surgery (p