PRENATAL STRESS INDUCES METABOLIC DISORDERS IN BALB/C MICE

YAMILA JUAREZ; ANA MARÍA GENARO; ADRIANA BURGUEÑO; JUAN CARLOS CALVO

Ciudad Autonoma de buenos Aires

Congreso; Reunion conjunta de sociedades de Biociencias; 2017

Sociedad Argentina de Investigacion Clinica

Prenatal exposure to maternal stress may program the fetal HPA axis, potentially leading to altered metabolism in later life, associated with obesity and diabetes. This effects could be worsen in adulthood if the individual doesn>t eat healthy. In the present work, westudied the effect of prenatal stress (PS) on metabolism and the impact of high fat diet (HFD). For this purpose pregnant BALB/c female mice were stressed by movement restriction during the last week of pregnancy leaving a control group (NPS). After weaning, mice were fed with HFD or a standard diet (SD). After 8 weeks of diet, PS+HFD females showed a higher body weight (BW) than the other groups (p