IRNASUS 26003
INSTITUTO DE INVESTIGACIONES EN RECURSOS NATURALES Y SUSTENTABILIDAD JOSE SANCHEZ LABRADOR S.J.
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A nanocrystals-based formulation improves the pharmacokinetic performance and therapeutic response of albendazole in dogs
Autor/es:
PAREDES, ALEJANDRO JAVIER; DIB, ALICIA; ALLEMANDI, DANIEL ALBERTO; SANCHEZ BRUNI, SERGIO; PALMA, SANTIAGO DANIEL; LITTERIO, NICOLÁS JAVIER; LANUSSE, CARLOS
Lugar:
Ciudad Autónoma de Buenos Aires
Reunión:
Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017
Institución organizadora:
Sociedad Argentina de Farmacología Experimental (SAFE) y otras
Resumen:
Albendazole (ABZ) is broad spectrum antiparasitic agent with a poor aqueous solubility which often leads to erratic bioavailability and therapeutic failures. For poorly soluble drugs, a diminution in particle size could lead to enhanced bioavailability and clinical efficacy. Nanocrystals (NC) are defined as nanoparticles composed of practically 100% drug, being generally stabilized by surfactants or polymeric steric agents and with a mean particle size is below 1 µm. Here we aimed to assess the pharmacokinetic performance and therapeutic response (anthelmintic efficacy) of an ABZ nano-sized formulation in dogs.
