BaCarb. A novel bioinorganic matrix for local drug delivery.

K. CESCAS; M. L. CACICEDO; V. E. BOSIO; G. R. CASTRO; L.M. PORTO

Florianopolis, Brasil

Congreso; 5th Congress of the Brazilian Biotechnology Society (SBBIOTEC); 2014

Brazilian Biotechnology Society

Treatment of localized tumor by chemotherapy is mostlyused as an adjuvant to surgery to protect against or delaythe progression of disseminated metastatic diseases or fortreatment when other local therapies, such as surgery arenot feasible. Local drug delivery offers high potential as atherapeutic choice against premature oncological stages orwith isolated cancers since it is more effective in reducingcancer recurrences and avoiding the undesirable sideeffects of drug spreading along the body [1]. Several applicationsof the bacterial cellulose in the biomedical fieldwere proposed, like wound healing membranes based onthe similarities to the human skin, artificial blood vessels,and as replacement of cornea, valve prosthesis, urethra,cartilage, etc. Also, the use of cellulose membranes hasbeen postulated for drug delivery of hormones andproteins and it was recently fully reviewed [2,3].Doxorubicin hydrochloride (dox) is commonly used in thetreatment of many solid tumors, such as breast, lung,stomach or ovarian cancer and sarcoma [4]. In the presentwork, we develop a bacterial cellulose membrane forencapsulation of Doxorubicin and containing l-Carr andCaCO3 as a potential implant device for local treatment ofsolid tumors. The in vitro Dox release kinetics from thematrices was studied at different pH values and also indifferent matrices.