VALPROATE (VPA), A HISTONE DEACETYLASE (HDAC) INHIBITOR, DECREASES FIBROSIS IN THE HYPERTROPHYC HEART OF SHR: TRH GENE EXPRESSION

LANDA, MARIA SILVINA; TOBLLI, JORGE E.; PERES DIAZ, LUDMILA; SCHUMAN, ML; PIROLA, CARLOS JOSÉ; AISICOVICH, M.; GARCIA, SILVIA INES

CABA

Congreso; LXII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2017

Cardiac TRH induces hypertrophy (LVH) and fibrosis in normal rats. Also, cardiac TRH system is overexpressed in SHR. It´s known that the histone deacetylase families, which modify the access of transcription factors to DNA, affect cardiac hypertrophy in animal models. As VPA is an inhibitor of HDACs and modulates gene expression through epigenetic alterations such as DNA methylation, we hypothesized that inhibition of HDACs with VPA might attenuate LVH and the fibrotic process in SHR by modulating cardiac TRH gene expression. 7 w-old male SHR and WKY received VPA. Blood pressure (BP) was recorded; after 10w of treatment rats were euthanized and hearts obtained. BP, LVH index and cTRH expression were increased in SHR vs WKY. VPA slightly attenuated (ANOVA,p