Maternal obesity impairs embryo development and causes aberrant embryo distribution prior to implantation.

GISELA SARRIBLE; MA. VICTORIA BAZZANO ; EVELIN M. ELIA ; DANTE A. PAZ

Ciudad de Buenos Aires

Congreso; Reunión Conjunta de las Sociedades Argentinas de Biociencias; 2017

Diverse signaling pathways, including adrenergic receptor beta 2 (â2AR) and lysophosphatidic acid receptor 3 (LPA3) have critical roles in embryo spacing and implantation. Using cafeteria diet-induced obesity as animal model, we previously found that obesity causes aberrant embryo distribution on gestation day (gd) 18.5 and 5.5 despite the total number of embryos was similar in both groups. However, on gd4.5 the total number of embryos was lower in the obese group compared to controls. Objective: analyze if these embryos were still in the oviduct and examine the potential role of the uterine â2AR and LPA3 signaling in causing the alteration in the embryo distribution on gd4.5. For that purpose uterine and oviductal flushings were performed on gd4.5. In control group all the embryos were in the uterus and the number of embryos was similar in both uterine horns. In obese animals some embryos were still in the oviduct and one horn/oviduct held more embryos then the contralateral (p