Biopsy Accuracy in Sjögren's Syndrome: Analysis of 803 Patients Presenting with Sicca Syndrome Referred to Labial Salivary Gland Biopsy

DIEGO BAENAS ; RETAMOZO SOLEDAD; NADIA BENZAQUÉN; MARÍA FLAVIA CEBALLOS ; MARIA JEZABEL HAYE SALINAS ; NADIA RISCANEVO ; ANA C. ALVAREZ; ALVARELLOS ALEJANDRO; JUAN PABLO PIROLA ; SOLEDAD FIORENTINO ; JANET FLORES ; CAEIRO FRANCISCO

San Diego

Congreso; ACR / ARHP ANNUAL MEETING; 2017

American College of Rheumatology

Background/Purpose:Labial salivary gland biopsy (LSGB) is a minimally invasive procedure used in the diagnostic ofSjögren?s Syndrome (SS). Objectives: to describe demographic, clinical and histological features of patients submitted to LSGB; to analyze the usefulness of LSGB in diagnosis of primary SS (pSS) and secondary SS (sSS); to assess the association between histological  findings and autoantibodies; to compare the sensitivity (Sn) and specicity (Sp) of the American-European 2002 (AE02) and ACR 2012 criteria.Methods:An observational, analytical, cross-sectional study was performed. A total of 803 patients were included between June 1996 and May 2016. A sub analysis of 674 patients was performed, excluding those with SSs and others without antibodies. Grades III and IV biopsy of the Chisholm and Mason´s (CM) classication were considered positive. Data was analyzed using STATA 17 software.Results:803 patients were included, 90% females. The mean age was 53 years (range 14-86). PSS was diagnosed in 238 (29.6%), and SS in 45 (5.6%), with female predominance in both groups (30.1% and 5.8%, respectively). Table 1 shows the clinical characteristics and complementary studies in patients with non specific dryness syndrome (NoSS) and SSP and SS.In the subanalysis of 674 patients, 33.1% were pSS, of which 204 (91.5%) were female. The mean agewas 54 years (range 14-86). LSGB was 0, I or II grades in 8.5% patients with PSS, versus 91.5% patientswith III-IV grades (p