Protective role of lipoic acid in the oxidative damage of brain structures in a glaucoma rat model

REIDES CLAUDIA; PEVERINI AGUSTINA; HVOZDA ARANA, AILEN GALA; JANEZIC, NATASHA; LASAGNI VITAR ROMINA; LERNER ; FERREIRA SANDRA MARIA; LLESUY, SUSANA

Mar del Plata

Congreso; LXI Reunion Cientifica Anual de la SAIC; 2016

Sociedad Argentina de Investigación Clínica

Evidence of oxidative process was found in glaucoma brain so the use of an antioxidant therapy may hold a promise for treatment. The purpose was to evaluate the possible protective role of lipoic acid (LA) in the oxidative damage of geniculate nucleus (GN) and visual cortex (VC) in an experimental glaucoma model. Wistar rats (3 months) weredivided in four groups (n=20): glaucoma in which rats were operated under a microscope by cauterized two of the episcleral veins (G), glaucoma treated with LA 100 mg/kg i.p. (LG), control which received a sham procedure (C) and control treated with lipoic acid 100 mg/kgi.p. (LC). Seven days after surgery rats were euthanized, brains were removed and GN and VC were separated. The following markers were evaluated:thioredoxin reductase (TRxR), glutathione reductase (GR) and superoxidedismutase (SOD) activities, protein oxidation (PO), damage to lipids (TBARS) and glutathione (GSH) Comparing LA treated glaucoma to glaucoma: TRxR increased 52% in GN (G 7.6±0.4 nmol/min.mg protein p