STUDY OF PISTACIA LENTISCUS var. CHIA FRUITS IN THE FRAMEWORK OF THE EUROPEAN PROJECT EXANDAS

EVGENIA ZERVA ; SERGIO ORTIZ; MARIA MAKROPOULOU ; MARIA EUGENIA ARISTIMUÑO FICOSECO; NAVEEN KUMAR; VASILIKI PACHI; STAMATIOS GIANNOUKOS, ; ILIAS SMYRNIOUDIS; BERND FIEBICH; DIEGO SAMPIETRO; SYLVIE MICHEL; NEKTARIOS ALIGIANNIS; RAPHAËL GROUGNET; SABRINA BOUTEFNOUCHET; MARINA KRITSANIDA

Bansko

Congreso; 3rd International Conference on Natural Products Utilization: From Plants to Pharmacy Shelf; 2017

Phytochemical Society of Europe

Exandas is a European project that unites 12 Academic and SME partners from European and North-African countries. Its aim is to study and exploit aromatic plant?s by-products in order to develop new cosmeceuticals and food supplements. Pistacia lentiscus var. chia (Anacardiaceae) is an evergreen tree, endemic of the Greek island of Chios. Its unique resin (mastic gum) is widely known and used for more than 2,500 years for its medicinal properties, especially against gastrointestinal disorders. A wide variety of products based on mastic gum are commercially available [1]. Renewable parts of this species, such as fruits, are not used in Greece, but can be found in the traditional medicines of other Mediterranean countries such as Algeria for the treatment of inflammation, burns and ulcer. To the best of our knowledge, the fruits of the Chios variety have never been studied before. Extensive extractions using ASE with c-Hex, EtOAc, MeOH and H2O were performed and the obtained extracts were evaluated for anti-oxidant, tyrosinase inhibitory, anti-fungal against the phytopathogenic fungus Fusarium graminearum and cytotoxic against the Bb2 microglia cell line activities. Due to promising results combined with low toxicity, bio-guided fractionation was then conducted and phenolic compounds such as anacardic acid derivatives have been identified and isolated from non-polar and polar fractions.