Cardiovascular risk factors programmed by zinc deficiency during growth.

ARRANZ CRISTINA; MENDES GARRIDO FACUNDO; GOBETTO, MARÍA NATALIA; CASTAÑÓN AGUSTINA; SCHAFER S; LUCERO D; ELESGARAY, ROSANA; SCHREIER LAURA; TOMAT ANALÍA

Congreso; 26th European Meeting on Hypertension and Cardiovascular Protection; 2016

ObjectiveModerate zinc deficiency during intrauterine and postnatal growth induces an increase in blood pressure levels,vascular remodelling and a decrease in vascular nitric oxide production in adult males.The objective was to evaluate serum metabolic profile and aortic function in adult male rats exposed to fetal and postnatal zinc deficiency.Design and methodFemale Wistar rats received during pregnancy up to weaning low (L:8 ppm) or control (C:30 ppm) zinc diet. After weaning, male offspring fed low (l) or control (c) zinc diet (Cc, Ll, Lc).until 81 days of life.At day 81, we measured systolic blood pressure (SBP,mmHg, tailcuff technique), serum fasting glucose and lipid profile. In aortic rings suspended in Krebs solution we evaluated: maximal contraction (Rmax) to phenylephrine (PE,109105M),angiotensinII (AngII,1010106M) and caffeine (25mM), expressed as % of maximal contraction with KCl 90mM. In aortic rings preconstricted with PE 105M,we measured the maximal relaxation with acetylcholine (ACh, 1010103M) and sodium nitroprusside (SNP, nitric oxide donor, 1011105M).ResultsValues are means±SEM, n=6/group. One way ANOVA, Bonferroni posttest*p