SEMANTIC INTERFERENCE DEFICITS AND THEIR RELATIONSHIP WITH SLEEP-WAKE PHENOTYPES IN ASYMPTOMATIC OFFSPRING OF LATE-ONSET ALZHEIMER`S AND ACUTE DISEASE PATIENTS

GUINJOAN, SALVADOR M; ABULAFIA, CAROLINA; LOEWENSTEIN, DAVID A; VILLARREAL, MIRTA F; DUARTE ABRITTA, BARBARA; GARCIA, CELESTE; BÄR, KARL-JÜRGEN; NEMEROFF, CHARLES B; DE GUEVARA, M. SOLEDAD LADRON; FIORENTINI, LETICIA; VIGO, DANIEL E

Londres

Congreso; Alzheimer`s Association International Conference (AAIC); 2017

Semantic interference memory deficits are an earlyclinical biomarker of Alzheimer?s Disease (AD), already presentin different groups with preclinical AD, as measured with theLASSI-L. We tested the hypothesis that SMD will be present in asample of middle-aged, cognitively normal adults with at leastone parent with sporadic AD (O-LOAD; n¼17), who are knownto have a heightened risk for the disorder, in comparison withhealthy subjects without any family history of AD (HC; n¼16).We further predicted that SMD would be associated in O-LOADwith disrupted sleep-wake variables in body temperature, motor activityand autonomic activity. Methods: LASSI-L was used inoffspring of sporadic AD patients and healthy controls to probe semanticinterference effects, along with quantification of a series oflimbic phenotypes including sleep-wake differences. Results: Allparticipants where within the normal range for standard cognitivetests and no significant differences were observed between groupsregarding regional brain volumes as explored with FreeSurfer in 3TMRI. Proactive semantic interference as indicated by more than 1intrusion in the 4B list had the greatest discriminative power (0%in HC vs. 50% in O-LOAD; p