ONCODRIVER INHIBITION AND TH1 CYTOKINES COOPERATE TO INDUCE TUMOR SENESCENCE AND APOPTOSIS IN HER2 AND TRIPLE NEGATIVE BREAST CANCER (TNBC)

CINTHIA ROSEMBLIT ; JASHODEEP DATTA; LEA LOWENFELD; SHUWEN XU; KRITHIKA KODUMUDI; DORIS WIENER; GRACIELA A CREMASCHI; BRIAN J CZERNIECKI

Ciudad Autónoma de Buenos AIires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedad Argentina de Investigación Clínica y 9 Sociedades Científicas más

Immune infiltration of breast cancer predicts favorable outcomes.We have described the loss of anti-oncodriver Th1 immunity duringbreast tumorigenesis. We studied the role that Th1 cytokines mayplay in the induction of tumor senescence and apoptosis of breastcancer cells.HER2positive cells were sensitive to senescence induction when culturedwith IFN-γ and TNF-α in a dose dependent manner measuredby β-galactosidase activity (p