FLUOXETINE AND SERTRALINE TREATMENT PREVENTS STRESS-INDUCED ALTERATIONS IN TUMOR CELL CYCLE PROTEINS RELATED TO ENHANCED TUMOR PROGRESSION IN EL4 LYMPHOMA. PARTICIPATION OF THE IMMUNE SYSTEM.

MARÍA EMILIA DI ROSSO ; HELENA STERLE; GRACIELA CREMASCHI ; ANA MARÍA GENARO

Ciudad Autónoma de Buenos AIires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedad Argentina de Investigación Clínica y 9 Sociedades Científicas más

Selective serotonin reuptake inhibitors, as fluoxetine (F) and sertraline(S), are frequently used for the treatment of stress-associateddisorders. However, there is contradictory evidence about theireffect on the immune system and cancer prognosis. We have previouslyreported that both F and S are able to revert chronic stressenhancement of EL-4 lymphoma growth. In the present work westudied the effect of F or S on chronic stress-induced alterations intumor cell cycle progression and in the anti-tumor immunity. FemaleC57BL/6J mice were treated with of F or S and subjected (E) or not(C) to a heterotrophic chronic stress for five weeks. Then, mice weresubcutaneously injected with EL4 T lymphoma cells to generate asolid tumor. Tumor mRNA expression of proteins related to regulationand promotion of cell cycle was assessed by qRT-PCR. mRNAlevels of cyclins A2, D1 and D3 were increased in tumor from E micecompared to C (P