INVESTIGADORES
BOCCIA Mariano Martin
congresos y reuniones científicas
Título:
Protein acetylation and synaptic composition during Inhibitory Avoidance Long-Term memory consolidation in mouse hippocampus.
Autor/es:
ESQUIVEL L.; SALLES A; BUSSO MJ; KRAWCZYK, MARÍA C.; BOCCIA, MARIANO M.; FREUDENTHAL R
Lugar:
Mar del Plata - BA
Reunión:
Congreso; SAN ANNUAL MEETING 2017; 2016
Institución organizadora:
SAN
Resumen:
Protein acetylation affects synaptic plasticity and memory, but its effects on synapse composition ?in vivo? during long term memory consolidation have not been addressed.Here we show that there is a correlation between the synaptic protein acetylation level and the synaptic protein composition at hippocampus during memory consolidation. We also show that altering the acetylation levels by administration of a Lysine deacetylase inhibitor specific for KDAC6 (mainly cytoplasmic) immediately after training facilitates retention at testing. These results suggest that the post translation modification, lysine acetylation, has a role regulating the synaptic changes that occur during memory consolidation.
