INVESTIGADORES
RISK Marcelo Raul
congresos y reuniones científicas
Título:
Numerical Simulation of Avascular Tumor Growth
Autor/es:
D FERNÁNDEZ SLEZAK, C SUÁREZ, A SOBA, M RISK AND G MARSHALL
Lugar:
San Juan, Argentina
Reunión:
Congreso; SABI 2007 - XVI Congreso Argentino de Bioingeniería; 2007
Institución organizadora:
Sociedad Argentina de Bioingeniería
Resumen:
A mathematical and numerical model for the description of different aspects of microtumor development is presented. The model is based in the solution of a system of partial differential equations describing an avascular tumor growth. A detailed second-order numeric algorithm for solving this system is described. Parameters are swiped to cover a range of feasible physiological values. While previous published works used a single set of parameters values, here we present a wide range of feasible solutions for tumor growth, covering a more realistic scenario. The model is validated by experimental data obtained with a multicellular spheroid model, a speci c type of in vitro biological model which is at present considered to be optimum for the study of complex aspects of avascular microtumor physiology. Moreover, a dynamical analysis and local behaviour of the system is presented, showing chaotic situations for particular sets of parameter values at some xed points. Further biological experiments related to those speci c points may give potentially interesting results.fferential equations describing an avascular tumor growth. A detailed second-order numeric algorithm for solving this system is described. Parameters are swiped to cover a range of feasible physiological values. While previous published works used a single set of parameters values, here we present a wide range of feasible solutions for tumor growth, covering a more realistic scenario. The model is validated by experimental data obtained with a multicellular spheroid model, a speci c type of in vitro biological model which is at present considered to be optimum for the study of complex aspects of avascular microtumor physiology. Moreover, a dynamical analysis and local behaviour of the system is presented, showing chaotic situations for particular sets of parameter values at some xed points. Further biological experiments related to those speci c points may give potentially interesting results.
