Reductive properties of (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-bis(diphenylmethylstannane

MA. GABRIELA MONTIEL SCHNEIDER; ANDREA R. COSTANTINO; SANDRA D. MANDOLESI; LILIANA C. KOLL

Conferencia; ECSOC-18 (18th International Electronic Conference on Synthetic Organic Chemistry); 2014

MDPI

The synthesis and application of (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-bis(diphenylmethylstannane) as reductive agent is reported. We focused on the reduction of bromo esters, inspired in the work of Metzger and co-workers. These compounds can be reduced by using an organotin halide and NaCNBH3 as a source of hydride. When the reaction of methyl 2-bromo-2-phenylbutanoate was performed in the conditions describe below, we observed that not only the reduction on the alpha position was achieved but also on the ester function.