Modulation of purinergic signaling has a tissue-dependent impact on the immune response against Trypanosoma cruzi infection

EBERHARDT, NATALIA; SANMARCO, LILIANA; GARCÍA, MÓNICA C; PONCE, NICOLÁS; THEUMER, MARTÍN; AOKI, MARÍA P.

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Adenosine (ADO), an immune-regulatory metabolite, is produced by hydrolysis of ATP that accumulates during tissue injury and inflammation. ADO generatedthrough CD73 activity is an extracellular signaling molecule that is involved in anti-inflammatory mechanisms and provides a feedback to control tissue damage mediated by the host immune response to several infections. We hypothesize that the balance between ATP and ADO is crucial in the Development of Chagas disease. The aim of this study was to determine the alance of purinergic signals and its impact in the host immune response developed in different T. cruzi target tissues. The kinetic of cardiac macrophage (Ma) subsets showed a predominant inflammatory/M1 profile throughout The acute infection (p