INVESTIGADORES
BOCCIA Mariano Martin
congresos y reuniones científicas
Título:
Acquisition of a new task impair memory consolidation of an inhibitory avoidance task in mice.
Autor/es:
BOCCIA MM; BLAKE MG; KRAWCZYK MC; CASAL J; BARATTI CM
Lugar:
Huerta Grande, Cordoba
Reunión:
Congreso; IRCN First Joint Meeting of the Argentine Society for Neuroscience (SAN) and the Argentine Workshop in Neurosciences (TAN); 2009
Institución organizadora:
Sociedad Argentina de Investigaciòn en Neurociencias y Taller Argentino de Neurociencias
Resumen:
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When a subject is exposed to
successive different learning experiences, the novelty of the second experience
can interfere the consolidation of memory of the first one. Novelty usually
induces a quick habituation, reflected by the rapid decrease of responding to
the new environment or situation. In this sense, the exposition of mice to the
nose-poke habituation task (NPH, second learning task) after training on the
inhibitory avoidance task (IA, first learning task), impaired retention
performance on the IA, indicating an interference caused by the second learning
situation. What is the reason for this interference? To gain
more insight on this question, in the present work we used the muscarinic
antagonist scopolamine (SCOP), a drug already known to cause anterograde, but
not retrograde amnesia at low doses. The dose of 0.5 mg/kg of SCOP given
immediately after training on the IA task, did not affect retention performance,
suggesting that consolidation of the IA is not affected. The same dose given 20
min before training on the NPH task, impaired performance, suggesting that it
blocks acquisition of the NPH. When mice were trained in the IA task, received
SCOP immediately after it, and 20 min later was exposed to the NPH task,
retention performance on the IA was not impaired. These results could be
suggesting that the blockade of the acquisition of the second task might be the
critical step causing the anterograde amnesia induced by the novel learning
situation.