Relevance of the galectin-1 (Gal1)-N-glycan axis in the development of spontaneous sialadenitis

V MARTINEZ ALLO ; V HAUK; R MORALES; E MARONNA; D CROCI; J STUPIRSKI; J CERLIANI; N PINTO; C PÉREZ LEIROS; G RABINOVICH ; M TOSCANO

Buenos Aires

Workshop; Simposio Argentino de Glicobiología (GlycoAr 2014).; 2014

FIL, IBYME, IFYBINE

Gal1, an endogenous β-galactoside-binding protein, plays a critical role in immune cell homeostasis and administration of rGal1 can suppress the clinical signs of autoimmunity and chronic inflammation. However, the role of endogenous Gal1 in the development of spontaneous autoimmunity has not yet been studied. Thus, we evaluated organs of aged Gal1 deficient mice (Lgals1-/-) and WT mice and found that salivary glands of Lgals1-/- mice (~20 mo) have increased weight and signs of inflammation compared to WT mice (P