Epidemiologic subsets drive a differentiated thoracic and extrathoracic presentation of sarcoidosis: analysis of 1082 patients from the SarcoGEAS-SEMI Registry

FRAILE, GUADALUPE; DE ESCALANTE BEGOÑA; VELILLA MARCO JOSE; TOLOSA VILELLA CARLES; PEREZ ALVAREZ ROBERTO; CALLEJAS JOSE LUIS; LÓPEZ DUPLA MIGUEL; SOLER FERRER CRISTINA; CHARA-FERNÁNDEZ JOEL; CRUZ-CAPARRÓS GRACIA; GARCIA MORILLO JS; PINILLA BLANCA; BONET MARIONA; ROBLES ANGEL; CALVO BEGUERIA EVA; MORCILLO CÉSAR; GÓMEZ CEREZO JORGE FRANCISCO; KOSTOV,BELCHIN; RODRÍGUEZ FERNÁNDEZ SERGIO; BRITO ZERON PILAR; AKASBI MIRIAM; VIVES M JOSE; DE VICENTE MOISÉS; PALLARES LUCIO; RETAMOZO SOLEDAD; GÓMEZ DE LA TORRE RICARDO; ALGUACIL ANA; RASCON JAVIER; FONSECA AIZPURU EVA; DE LA RED BELLVIS GLORIA; PERAL GUTIÉRREZ DE CEBALLOS ENRIQUE; PEREZ GUERRERO PATRICIA; GATO DIEZ ALBERTO; OJEDA INMACULADA; PENADÉS VIDAL MARÍA; RAMOS CASALS MANUEL

San Diego

Congreso; ACR / ARHP ANNUAL MEETING; 2017

American College of Rheumatology

OBJECTIVE. To analyse whether epidemiologic factors (such as gender or age at diagnosis of the disease) are associated with particular disease expressions and define specific epidemiological subsets in patients with sarcoidosis. Methods. In January 2016, the Autoimmune Diseases Study Group (GEAS-SEMI) created a national registry (SARCOGEAS) of patients with sarcoidosis. Sarcoidosis was diagnosed in agreement with the criteria proposed by the American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) 1999 statement on sarcoidosis. Organ involvement was retrospectively determined in each patient at the time of diagnosis using the 2014 WASOG organ assessment instrument. Ethnicity was defined according to the FDA classification. Results. The cohort consisted of 1082 patients (82% biopsy-proven), including 618 (57%) women and 464 (43%) men, with a mean age at diagnosis of 47.2 ± 15.5 years. One hundred forty (13%) patients were born outside Spain. With respect to the FDA ethnic classification, 965 (89%) patients were classified as White, 69 (6%) as Hispanic, 30 (3%) as Black/African American and 18 (2%) as Asian. Thoracic involvement was present at diagnosis in 979 (90%) patients, including 437 (40%) patients presenting with stage I, 374 (35%) with stage II, 123 (11%) with stage III and 26 (2%) presenting with stage IV. According to the WASOG classification, the most frequently reported extrathoracic involvements at diagnosis were cutaneous in 385 (36%) patients, extrathoracic lymph nodes in 218 (20%), liver involvement in 151 (14%) and ocular involvement in 118 (11%).In the multivariate analysis models, women showed a lower frequency of thoracic involvement (87% vs 93% in men, p=0.019) and a higher frequency of cutaneous (42% vs 26%, p