Perigestational alcohol consumption up to early organogenesis

VENTUREIRA V, SOBARZO C, CHALIMONIUK C, BARBEITO C, CEBRAL E

Argentina

Congreso; Reunion Conjunta de Sociedades de Biociencias; 2017

Sociedades Argentinas de Ciencias Biomédicas

Maternal alcohol consumption leads to congenital diseases andorgan malformation, in which the developing heart is one of maintarget for teratogenic maternal alcohol effects. The aim of this studywas to assess if perigestational alcohol intake up to day 10 of gestation(D10) alters the heart rate and ventricular and atrial myocardialand endocardial arrangement, and modifies the proliferation andapoptotic indexes, in fetal heart at day 13 of gestation (D13). Ethanol10% in drinking water was administered to murine CF-1 females for15 days before and up to D10, and gestation continued with wateruntil D13 (treated females (TF)). Control females (CF) were administeredwith drinking water without ethanol. Both in morphologicallyabnormal and normal fetuses of TF, the hearts presented thinnertrabeculation and discontinuous endocardium (Hematoxylin-eosin),and the ventricular and atrial myocardial wall thickness were reduced(p