Development and in vitro evaluation of miltefosine-loaded polymeric micelles

VALENZUELA-OSES, JOHANNA; GARCÍA, MÓNICA C; GOMES-FILHO, SANDRO; LOURENÇO, FELIPE; BASSÉRES, DANIELA; RANGEL-YAGUI, CARLOTA

Congreso; 4º Reunión Internacional de Ciencias Farmacéuticas-RICiFa.; 2016

Miltefosine (MT) is an alkylphosphocholine drug with antineoplastic activity but high hemolytic potential1. In this work, we encapsulated MT into polymeric micelles of the copolymer Pluronic F127 (PF127). A central composite design was applied to optimize the formulation parameters and to study the effects of hydration temperature, stirring speed and stirring time on the hydrodynamic diameter (Dh) and polydispersity index (PI) (response variables)2. Second order models were obtained to adequately describe the influence of the independent variables on the selected response. Analysis of variance showed that temperature had significant effect (p