INVESTIGADORES
GARGIULO MONACHELLI Gisella Mariana
congresos y reuniones científicas
Título:
Pharmacological effects of testosterone in a mouse model of motoneuron disease.
Autor/es:
AGUSTINA B LARA; GARGIULO MONACHELLI GISELLA; MARIA MEYER; LAURA GARAY; NOELIA DI GIORGIO; VICTORIA LUX-LANTOS; MICHAEL SCHUMACHER; GENNOUN R; DE NICOLA AF; GONZALEZ DENISELLE M.C
Reunión:
Congreso; Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC).; 2016
Resumen:
Pharmacological effects of testosterone in a mouse model of motoneuron disease.Lara Agustina, Gargiulo Monachelli Gisella, Meyer María, Garay Laura, Di Giorgio Noelia, Lux-Lantos Victoria, Schumacher Michael, Guennoun Rachida, De Nicola Alejandro and Gonzalez Deniselle María Claudia Wobbler (WR) mouse, a useful model for human amyotrophic lateral sclerosis (ALS), shows motoneuron degeneration with increased levels of intramitochondrial nitric oxide synthase (NOS) and astrogliosis in the spinal cord. Some steroids such as progesterone favor mitochondrial function and neuroprotection, while others are deleterious. Here, we determined endogenous testosterone (T) levels in male WRs and controls by radioimmunoassay and gas chromatography/mass spectrometry (GC/MS) at symptomatic stage. We demonstrated a strong decrease of T levels in serum, spinal cord and brain (p