GOS/FOS® as a tool to improve bone health in a model of osteopenia.

BRYK G; HERNANDEZ E; ZENI CORONEL MAGALÍ,; DE PORTELA ML; LUGONES C; MANDALUNIS P; ZENI SN

Rotterdam

Congreso; The 4th Joint Meeting of ECTS and IBMS Rotterdam; 2015

International Bone & Mineral Society

Same nondigestible oligosaccharides (NDOs) stimulates Ca and phosphorus (P) absorption and improves bone mass. The effect of NDOs appears to be more important when the diet does not met Ca nutritional recommendations. Estrogen deficiency induces a loss of bone mass which is greater if the intake of Ca is insufficient. Objective: to evaluate the effect a mixture of galactooligosaccharides (GOS) and fructooligosaccharides (FOS) (GOS/FOS®) (9:1) added to a low or a normal Ca diet on Ca and P absorption, bone retention, mineralization and structure in osteopenic-estrogen deficient rats. Female adult Wistar rats were OVX and remained untreated for 45 days to become osteopenic. Then, they were randomly assigned to receive for an additional 45-day period (T90) one of the following treatment: C5: AIN93-M containing 0.5% Ca; P5: C5 +2.5% GOS/FOS®, C3: AIN93-M containing 0.3% Ca; P3: C3 +2.5% GOS/FOS®. Body weight (BW) and intestinal lactobacilli count (UFC) were evaluated weekly. Ca and P absorptions were assessed at baseline and T90. Caecum pH, femoral Ca and P content, total skeleton BMC and BMD (Lunar DXA), bone volume (BV/TV), bone-breaking strength, elastic modulus and stiffness were determined at T90. Results: No differences in BW were observed. Caecum pH decreased while UFC (p