OBESITY CAUSES ABERRANT UTERINE EMBRYO DISTRIBUTION AND MACROSOMIA AT TERM

BAZZANO MARÍA VICTORIA; PAZ, DANTE AGUSTÍN; ELIA, EVELIN MARIEL

Congreso; SLIMP / SCHCF Joint Meeting 2017. Latin American Society for Maternal Fetal Interaction and Placenta (SLIMP); 2017

Latin American Society for Maternal Fetal Interaction and Placenta (SLIMP)

OBESITY CAUSES ABERRANT UTERINE EMBRYO DISTRIBUTION AND MACROSOMIA AT TERMThe prevalence of obesity is increasing worldwide. It is related to several reproductive disorders but the molecular mechanisms linking them remain unclear. Using cafeteria diet-induced obesity as animal model, we found that obesity causes aberrant uterine fetal distribution and macrosomia at term (gestation day (gd) 18.5) when compared to controls. To elucidate whether this alteration is consequence of fetal re absorptions or due to alterations in the foregoing embryo spacing, we analyzed embryo distribution just after implantation time (on gd5.5).We also found asymmetric uterine embryo distribution on gd 5.5, indicating that to obesity alters the uterine embryo distribution prior to implantation. Then, to analyze embryo distribution just before implantation, uterus from rats at gd 4.5 were flushed and embryos were collected. The total number of embryos detected in obese rats was lower than in controls (p