Myelodysplasia-related mortality remains the main cause of death along different groups of risks: an analysis from MDS Argentinean Study Group

BASQUIERA, ANA L; ENRICO, ALICIA; ARBELBIDE, JORGE; NUCIFORA, ELSA; IASTREBNER, MARCELO; FLORES, GABRIELA; GONZALEZ, JACQUELINE; CRISP, RENÉE; BELLI, CAROLINA

Madrid

Congreso; 22nd Congress Of The European Hematology Association; 2017

EHA

Background: Myelodysplastic syndrome (MDS) are the most frequent hematological malignancy in elderly patients. The impact of MDS burden over overall mortality remains controversial, moreover, after the incorporation of hypometilating agents in the therapeutic armamentarium.Aim: We aimed to analyze overall mortality and causes of death in our population of patients with MDS.Methods: retrospective analysis of patients with MDS reported to Argentinean MDS registry and a previous study from Academia Nacional de Medicina. Causes of death were classified in: acute myeloid leukemia (AML), infections, bleeding, solid tumor, cardiovascular, transplant related mortality (MRT), others and unknown. AML, infections and bleeding were joined as MDS-related mortality. Causes of death were analyzed using cumulative competitive events curves with Gray test and Fine-Gray for proportional hazard regression was used for the multivariate analysis. Results:From 1981 to 2016, 1040 patients with MDS were recorded; 717 out of 1040 (69%) were diagnosed after 2006. Median age of patients was 70 years (range: 14 ? 95 years) with 588 (56%) being male. MDS was primary in 974 patients (94%). Median follow-up of 25 months (range: 1 ? 170 months) for the surviving patients. The cumulative incidence of overall mortality was 20% at 12 months (95%CI 2-22), 37% at 24 months (95%CI 3-40) and 59% at 60 months (95%CI 5-63). The incidence of overall mortality did not significantly differ along the years of diagnosis (p=0.291) neither according to age group. Multivariate analysis for cumulative incidence of overall mortality found Charlson index (HR 1.38; p