BIOMED   24552
INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
THE IMPACT OF THE PRENATAL STRESS IN THE DEVELOPMENT OF OBESITY
Autor/es:
MARIA ROSA GONZALEZ MURANO; ALEJANDRO EMILIANO MERCADO,; ADRIANA LAURA BURGEÑO; YAMILA JUAREZ; ANA MARIA GENARO
Lugar:
Mar del Plata
Reunión:
Congreso; LXI ANNUAL MEETING ARGENTINE SOCIETY FOR CLINICAL INVESTIGATION (SAIC) LXIV ANNUAL MEETING ARGENTINE SOCIETY OF IMMUNOLOGY (SAI) XLVIII ANNUAL MEETING ARGENTINE SOCIETY OF EXPERIMENTAL PHARMACOLOGY (SAFE) VII ANNUAL MEETING ARGENTINE SOCIETY OF NANOMEDICI; 2016
Institución organizadora:
SAIC, SAFE, SAI
Resumen:
According to the ?fetal programming hypothesis, prenatal exposureto suboptimal intrauterine conditions could predispose theindividual to chronic disease at adult age. ver the past decades,obesity has increased its orldide prevalence. Therefore identifyingthe factors that predispose its development is essential. n thepresent or, e studied the effect of prenatal stress S on thedevelopment of obesity. For this purpose pregnant CL/ femalemice ere stressed during the last ee of pregnancy for h dailyfrom A to by placing them in a plastic restraining tube.onexposed control pregnant females ere left undisturbed duringall the gestation period S. At th ee of age, both S andS offspring ere fed ith one of the folloing diets High Fat dietHF, cal/g or a standard diet S, cal/g. After ees of diet, S/S males shoed no differences in body eightcompared to S/S. nstead, S/HF males gained more bodyeight than the S/HF p .. ithin the group of S malese observed that those fed ith HF had more body eight thanS p .. After ees of diet e observed a difference inbody eight beteen S/HF vs S/S females p.. nliemales, S/HF vs S/HF females did not sho a difference intheir body eight. hen e performed a glucose tolerance test, eobserved that all males S S fed ith HF shoed a higherarea under the curve than those ho ere fed ith S p..hile females shoed no significant difference. e conclude thatthe S predisposes the development of obesity in male mice, butthis only happens under the intae of a HF. Furthermore, theseresults suggest that exists a sexual dimorphism response to thedevelopment of obesity after prenatal stress.