INSIBIO   05451
INSTITUTO SUPERIOR DE INVESTIGACIONES BIOLOGICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Evidence of gastroprotective effect of Acacia aroma Gill ex Hook&Arn (Tusca) leaves infusion
Autor/es:
NATALIA HABIB; FACUNDO TABOADA; SUSANA GENTA
Lugar:
Mar del Plata
Reunión:
Congreso; XLVIII REUNION ANUAL DE LA ASOCIACION ARGENTINA DE FARMACOLOGIA EXPERIMENTAL; 2016
Institución organizadora:
Asociación Argentina de Farmacología Experimental
Resumen:
Acacia aroma ill ex HooArn., Tusca, is an autochthonousherb of orthest Argentina. The peptic ulcer is a pathology resultingof the imbalance beteen offensive and defensive factors in gastricmucosa and the search for ne treatments is a current challenge.The aim of the present study as to evaluate the potential gast roprotectiveand antisecretory effects of infusion of Tusca leaves.This extract as lyophilized and subjected to a phytochemicalscreening, and its antioxidant activity as determined. In vivo studiesere developed in to models of induced gastric ulcers in maleistar rats ethanol and pylorus ligation. The experimental groupsn animals/group ere Control group ositive controlgroup treated ith Sucralfate mg/g or meprazole mg/g orally Aqueous extract treated group received orally mg dry extract /g. ucus content as evaluated by Alcian luemethod and ulceration parameters number of ulcers, severityand ulcerated area percentage ere determined. Chemical, microscopicstudies of gastric content and a histological evaluationere performed. Also, a gastric emptying assay as carried out.Tusca extract shoed a significant free radical scavenging effect,compared ith the controls quercetin and HT. The extract causeda significant p . decrease of the ulcerated area, being theseverity and number of ulcers loer, compared ith untreatedcontrol group, the mucus content as significantly higher thancontrol group. The rats treated ith the extract shoed a decreasein the gastric juice volume and free acidity compared ith controlgroup. The gastric emptying as no modified ith the treatment. nconclusion, Tusca extract has a significant gastroprotective effectliely related to free radical scavenging activity and through thestrengthening of the mucus layer. Additional studies are neededto determine the active compounds and specific mechanismsinvolved.