Corneal burn in one eye leads to neurogenic conjunctival inflammation of the fellow eye.

GALLETTI JEREMÍAS GASTÓN; GUZMÁN MAURICIO; KEITELMAN IRENE; SABBIONE FLORENCIA; TREVANI ANALÍA SILVINA; GIORDANO MIRTA NILDA

Conferencia; Gordon Research Conference; 2016

In the clinic, it is commonly accepted that both eyes are functionally independent, but we unexpectedly observed immune tolerance perturbations in the opposite eye after unilateral manipulation in mice. Since there is no ocular lymphatic cross drainage that could account for this contralateral change, we studied the effect of a unilateral corneal lesion on conjunctival mucosal tolerance of the fellow eye. Using a delayed-type hypersensitivity (DTH) assay after s.c. immunization with ovalbumin (OVA)+adjuvant in Balb/c mice, we observed observed reduced responses in OVA-instilled mice compared with control mice (p