The thyroid status modulates the 4T1 breast cancer development in vivo through the regulation of cell proliferation, the composition of tumor microenvironment and the antitumor immune response.

STERLE HA, ; PAULAZO A, ; AMORÓS M, ; HILDEBRANDT X, ; GARCÍA M, ; BOLONTRADE M, ; CREMASCHI GA.

Mar del Plata

Congreso; LXI Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2016

SAIC y SAI

The tumor development is regulated by a wide range of factors,including hormones produced by the endocrine system. However,very little is known about the influence of thyroid hormone (TH)levels on tumor growth. Previously we showed that THs are ableto regulate the antitumor immune response. Our aim was to evaluatethe effect of thyroid status on the development of 4T1 breastcarcinoma in syngeneic mice. For this, Balb/c mice were treatedwith thyroxine (12mg/l) for 30 days or propylthiouracil (500mg/l)for 15 days in the drinking water to obtain hyperthyroid (hyper) orhypothyroid (hypo) mice, respectively. Mice were then inoculateds.c with 4T1 cells.Hyper mice showed an increased tumor growthrate (p