Role of HLA-DP and HLA-DQ on the protection against chronic Hepatitis B virus (HBV) infection and viral clearance in two regions of Argentina with dissimilar ancestry genetic background

TRINKS J; HULANIUK ML; CAPUTO M; TSUCHIURA T; MARCIANO S; HADDAD L; BLEJER J; BARTOLI S; AMEIGEIRAS BM; FRIAS S; VISTARINI C; HEINRICH F; REMONDEGUI C; CEBALLOS S; ECHENIQUE G; CHARRE SAMMAN M; D'AMICO C; ROJAS A; MARTÍNEZ A; RIDRUEJO E; FERNANDEZ R; BURGOS PRATX L; SALAMONE H; NUÑEZ F; GALDAME O; GADANO A; CORACH D; SUGIYAMA M; FLICHMAN D; NISHIDA N; TOKUNAGA K; MIZOKAMI M

Boston

Congreso; The Liver Meeting 2016; 2016

American Association for the study of the Liver Diseases (AASLD)

HBV infection has become a serious problem among Native Americans in the Amazon Basin and in other Amazon-related ecological systems from South America. While HBV rates are low in the central and metropolitan region of Argentina (MET), the Northwestern region (NWA) exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are unknown. Hence, 1440 Argentines were recruited and defined into 3 groups: HBV patients (201 from MET and 200 from NWA) who were HBsAg(+) for more than 6 months, HBV resolved individuals (318 from MET and 313 from NWA) who were HBsAg(-)/total anti-HBc antibodies(+), and healthy controls (207 from MET and 201 from NWA) who were negative for both markers. Genetic ancestry was assessed by analysis of bi-parental lineages and ancestry autosomal typing in all samples. SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were also determined. HBV genotyping was performed by phylogenetic analysis in HBsAg(+) samples. Native American ancestry prevailed in NWA when compared with MET (p