Effect of a heat-killed Mycobacterium avium subsp. paratuberculosis vaccine using a modified Vaccinia Ankara virus expressing antigen 85A (MVA85A) of Mycobacterium bovis as a boost in a murine model challenge.

MARIA ALEJANDRA COLOMBATTI OLIVIERI; ROBERTO DAMIÁN MOYANO; VALERIA NOELY MONTENEGRO; MARIA LAURA MON; MARIANA VIALE; ALONSO MARIA NATALIA; PAULA DEL MEDICO; MARIA DE LA PAZ SANTANGELO; DELGADO FERNANDO; ROMANO MARIA ISABEL

Nantes

Congreso; 13th International Colloquium on Paratuberculosis; 2016

International association for paratuberculosis

Paratuberculosis is a chronic disease caused by Mycobacterium avium subsp. paratuberculosis (Map). Considering the economic it is necessary to control the disease and to develop an efective vaccine. BALB /c mice are the experimental model of choice for initial screening of vaccines candidates. To evaluate the protection conferred in the murine model using the prime-boost strategy with a virulent local strain inactivated MVA85A in order to find a better vaccine candidate.