Heterogenety Clinic of Dementia and Apraxia Severity in Alzheimer Disease Patients

POLITIS DANIEL GUSTAVO, RUBINSTEIN WANDA YANINA

Buenos Aires

Congreso; 2008 Mild Year Meeting of the International Neuropsychological Society and the VIII SONEPSA Meeting; 2008

International Neuropsychological Society - SONEPSA

Objective : Clinical Alzheimer Disease (AD) evolution introduced large clinical heterogeneity. While some studies with patients with AD found that apraxia is a function early altered their relationship to clinical diversity has not been severely studied. It had been described different clinical subtypes; Mayeux reported the existence of 4, which have different levels of severity and cognitive function. The clinic diversity has not been clearly investigated. Objectives: study the relation between Mayeux clinical subtypes, dementia severity, limb apraxia and functional decline in AD patients. While some studies with patients with AD found that apraxia is a function early altered their relationship to clinical diversity has not been severely studied. It had been described different clinical subtypes; Mayeux reported the existence of 4, which have different levels of severity and cognitive function. The clinic diversity has not been clearly investigated. Objectives: study the relation between Mayeux clinical subtypes, dementia severity, limb apraxia and functional decline in AD patients. While some studies with patients with AD found that apraxia is a function early altered their relationship to clinical diversity has not been severely studied. It had been described different clinical subtypes; Mayeux reported the existence of 4, which have different levels of severity and cognitive function. The clinic diversity has not been clearly investigated. Objectives: study the relation between Mayeux clinical subtypes, dementia severity, limb apraxia and functional decline in AD patients. Clinical Alzheimer Disease (AD) evolution introduced large clinical heterogeneity. While some studies with patients with AD found that apraxia is a function early altered their relationship to clinical diversity has not been severely studied. It had been described different clinical subtypes; Mayeux reported the existence of 4, which have different levels of severity and cognitive function. The clinic diversity has not been clearly investigated. Objectives: study the relation between Mayeux clinical subtypes, dementia severity, limb apraxia and functional decline in AD patients. Participants and Methods: We tested 49 AD patients. We administered the Praxis Battery (Politis & Margulis) and used the Index of Katz and Questionnaire of Lawton & Brody to see the performance in the basic activities of daily living and the Instrumental activities of daily living. We used Clinical Dementia Rating, el Global Deterioration Scale and Mini-Mental State Examinantion to assess severity of dementia. (Politis & Margulis) and used the Index of Katz and Questionnaire of Lawton & Brody to see the performance in the basic activities of daily living and the Instrumental activities of daily living. We used Clinical Dementia Rating, el Global Deterioration Scale and Mini-Mental State Examinantion to assess severity of dementia. (Politis & Margulis) and used the Index of Katz and Questionnaire of Lawton & Brody to see the performance in the basic activities of daily living and the Instrumental activities of daily living. We used Clinical Dementia Rating, el Global Deterioration Scale and Mini-Mental State Examinantion to assess severity of dementia. We tested 49 AD patients. We administered the Praxis Battery (Politis & Margulis) and used the Index of Katz and Questionnaire of Lawton & Brody to see the performance in the basic activities of daily living and the Instrumental activities of daily living. We used Clinical Dementia Rating, el Global Deterioration Scale and Mini-Mental State Examinantion to assess severity of dementia. Results : We found strong relationship between Mayeux classification and dementia severity, apraxia severity and functional decline. apraxia severity and functional decline. apraxia severity and functional decline. We found strong relationship between Mayeux classification and dementia severity, apraxia severity and functional decline. Conclusions : Dementia severity, apraxia severity and functional decline seems to accompany the different clinical subtypes described by Mayeux, thus the detection and evaluation of the same could contribute to the AD clinical classification and prognosis accompany the different clinical subtypes described by Mayeux, thus the detection and evaluation of the same could contribute to the AD clinical classification and prognosis accompany the different clinical subtypes described by Mayeux, thus the detection and evaluation of the same could contribute to the AD clinical classification and prognosis Dementia severity, apraxia severity and functional decline seems to accompany the different clinical subtypes described by Mayeux, thus the detection and evaluation of the same could contribute to the AD clinical classification and prognosis